MACF1
білок-кодуючий ген Homo Sapiens
MACF1 (англ. Microtubule-actin crosslinking factor 1) – білок, який кодується однойменним геном, розташованим у людей на короткому плечі 1-ї хромосоми. [3] Довжина поліпептидного ланцюга білка становить 7 388 амінокислот, а молекулярна маса — 838 308[4].
Послідовність амінокислот
| 10 | 20 | 30 | 40 | 50 | ||||
|---|---|---|---|---|---|---|---|---|
| MSSSDEETLS | ERSCRSERSC | RSERSYRSER | SGSLSPCPPG | DTLPWNLPLH | ||||
| EQKKRKSQDS | VLDPAERAVV | RVADERDRVQ | KKTFTKWVNK | HLMKVRKHIN | ||||
| DLYEDLRDGH | NLISLLEVLS | GIKLPREKGR | MRFHRLQNVQ | IALDFLKQRQ | ||||
| VKLVNIRNDD | ITDGNPKLTL | GLIWTIILHF | QISDIYISGE | SGDMSAKEKL | ||||
| LLWTQKVTAG | YTGIKCTNFS | SCWSDGKMFN | ALIHRYRPDL | VDMERVQIQS | ||||
| NRENLEQAFE | VAERLGVTRL | LDAEDVDVPS | PDEKSVITYV | SSIYDAFPKV | ||||
| PEGGEGISAT | EVDSRWQEYQ | SRVDSLIPWI | KQHTILMSDK | TFPQNPVELK | ||||
| ALYNQYIHFK | ETEILAKERE | KGRIEELYKL | LEVWIEFGRI | KLPQGYHPND | ||||
| VEEEWGKLII | EMLEREKSLR | PAVERLELLL | QIANKIQNGA | LNCEEKLTLA | ||||
| KNTLQADAAH | LESGQPVQCE | SDVIMYIQEC | EGLIRQLQVD | LQILRDENYY | ||||
| QLEELAFRVM | RLQDELVTLR | LECTNLYRKG | HFTSLELVPP | STLTTTHLKA | ||||
| EPLTKATHSS | STSWFRKPMT | RAELVAISSS | EDEGNLRFVY | ELLSWVEEMQ | ||||
| MKLERAEWGN | DLPSVELQLE | TQQHIHTSVE | ELGSSVKEAR | LYEGKMSQNF | ||||
| HTSYAETLGK | LETQYCKLKE | TSSFRMRHLQ | SLHKFVSRAT | AELIWLNEKE | ||||
| EEELAYDWSD | NNSNISAKRN | YFSELTMELE | EKQDVFRSLQ | DTAELLSLEN | ||||
| HPAKQTVEAY | SAAVQSQLQW | MKQLCLCVEQ | HVKENTAYFQ | FFSDARELES | ||||
| FLRNLQDSIK | RKYSCDHNTS | LSRLEDLLQD | SMDEKEQLIQ | SKSSVASLVG | ||||
| RSKTIVQLKP | RSPDHVLKNT | ISVKAVCDYR | QIEITICKND | ECVLEDNSQR | ||||
| TKWKVISPTG | NEAMVPSVCF | LIPPPNKDAI | EMASRVEQSY | QKVMALWHQL | ||||
| HVNTKSLISW | NYLRKDLDLV | QTWNLEKLRS | SAPGECHQIM | KNLQAHYEDF | ||||
| LQDSRDSVLF | SVADRLRLEE | EVEACKARFQ | HLMKSMENED | KEETVAKMYI | ||||
| SELKNIRLRL | EEYEQRVVKR | IQSLASSRTD | RDAWQDNALR | IAEQEHTQED | ||||
| LQQLRSDLDA | VSMKCDSFLH | QSPSSSSVPT | LRSELNLLVE | KMDHVYGLST | ||||
| VYLNKLKTVD | VIVRSIQDAE | LLVKGYEIKL | SQEEVVLADL | SALEAHWSTL | ||||
| RHWLSDVKDK | NSVFSVLDEE | IAKAKVVAEQ | MSRLTPERNL | DLERYQEKGS | ||||
| QLQERWHRVI | AQLEIRQSEL | ESIQEVLGDY | RACHGTLIKW | IEETTAQQEM | ||||
| MKPGQAEDSR | VLSEQLSQQT | ALFAEIERNQ | TKLDQCQKFS | QQYSTIVKDY | ||||
| ELQLMTYKAF | VESQQKSPGK | RRRMLSSSDA | ITQEFMDLRT | RYTALVTLTT | ||||
| QHVKYISDAL | RRLEEEEKVV | EEEKQEHVEK | VKELLGWVST | LARNTQGKAT | ||||
| SSETKESTDI | EKAILEQQVL | SEELTTKKEQ | VSEAIKTSQI | FLAKHGHKLS | ||||
| EKEKKQISEQ | LNALNKAYHD | LCDGSANQLQ | QLQSQLAHQT | EQKECRAVAG | ||||
| VIDLGTVEIF | PIFKAMQKGL | LDQDTGLVLL | ESQVIMSGLI | APETGENLSL | ||||
| EEGIARNLIN | PQMYQQLREL | QDALALISRL | TESRGPLSVV | EAIEKRIISE | ||||
| TVGLKILEAH | LATGGFSLSP | SENCINLEEA | FHQGLISAWL | HSVLESYLRT | ||||
| SKNLIDPNTA | EKIGLLDLMQ | RCIVHQESGF | KLLPVKQLAG | GMVSLKSGRK | ||||
| VSIFRAVQEG | LIDRQVTVRL | LEAQLFAGGI | VDPRTGHRLT | VEEAVRHNLI | ||||
| DQDMACAILI | RQLQTGGIID | TVTGQRLTID | EAVSNDLVAA | KIALVILESL | ||||
| WSFMGLLWPE | SGEILPITDA | LEQGIVSTEL | AHKILSNRQH | IKALFLPATT | ||||
| EILSWKKAIE | SGILDRDLAN | NLKSICIPDV | MPHMQLADSA | EQNINPGAAV | ||||
| LPCSKSHPKA | TASQSENLLF | QLMTHSYINV | QNGQRLLLLD | KELMETLTSR | ||||
| DEYQTSPPKV | VEIGHQRQKT | PEGLQESANV | KISGTFSSGW | TVRLPEFQFS | ||||
| SQNKEYPDRE | DCTTEKGKKT | TVETEDSSVE | NPEQDLFVEQ | KERNPNIDAL | ||||
| KVINKVKLEV | QRQLIGTQRE | DQTAVSVREN | ASRGHLLTIP | PAEAEGVPLV | ||||
| VDKDVFSVET | PKKEHQPLRN | TSFTCQNEQA | HTLETEYIHD | ETGGSHIKPQ | ||||
| SKKLQVQVKK | TLGIKLELKS | ETDGNVHPLD | KKEMLKKTFL | AKDDHKESQE | ||||
| AQNIAGGSMM | MSEKTDEEDS | GREIFLSCSH | PLELLEEATL | NVLSAQLLDG | ||||
| GIFHEQTGQK | LLLNEAISRG | IVPSHTAVKL | MEKLNMFQGF | FDSQTCESLT | ||||
| TEEVINEGLM | DEKLLHNVLM | ADKAISGVLD | PRTQTLCSVK | DAVTVGLLDK | ||||
| ETATRILERQ | VVTGGIIDLK | RGKKVSVTLA | STLGLVDVAD | QPELINLEKA | ||||
| SKGRDAEKTV | RERLISLQME | TTGLIDPDSK | APLTVVQSID | RGLLEREEAV | ||||
| RLLTKQVVDG | GIIHHISGMR | LSVDNAFRHG | LIGEDLAEKL | KRVENLNIHQ | ||||
| IFNPETKENI | SLPKAIKLDL | ITSDLKREIQ | EVQAFTGNFV | DLISGQRLTL | ||||
| AEAKKEGLLT | NEAVLSPGMM | HGIVDPENCR | IVPYSELVKK | CKIDIESGQR | ||||
| YLEVIPFSDI | KDGVSDKVLT | LSQAIQLGKV | DFASTLKVLE | AQANTGGIID | ||||
| TATGKRLTLA | SALEEKLVDE | NMVRIIASHQ | VLNGGIVDIF | SDQRVTLVEA | ||||
| IEKRLISPEL | ANMIQIDSSE | FSDHRAQIEK | QEGIEVCALQ | NEFLGKDMLI | ||||
| ACNQTAEMSC | NKVEESERLF | QVENQSAQEK | VKVRVSDGEQ | AKKSREISLK | ||||
| EFGCKDQRKP | RMSSDAKEFI | SIINPHNLKG | KSLGQVSLTH | PYSECDFKLK | ||||
| EVARNNMGND | TNEEQEKAVT | KIEIISHMKQ | STSCLDSEEI | RENQGEVILE | ||||
| VQETYCETSG | KLPSEQVLQQ | PMNARVKSKR | EKREVIVEES | IRTCKPAFLS | ||||
| EEKLYQETAI | RDEHDSHIKS | QPREMTSSEK | GKEADTEMGF | SITFKIEESS | ||||
| SQVVPQGISV | KHLDALTLFS | SKQANEGKVN | NLSLCLTLKP | EENLSREIAC | ||||
| GAQSEPFPCM | TPRPEGLHYQ | ESDGKAQVTG | PSQISKTDKS | FQGTTRQETN | ||||
| YQDSWVTSKT | KETKHQISSS | NECKEKSYQE | VSFDPARGLK | LEEITVSRPD | ||||
| SKEVRYLEFS | DRKDLHHQGS | KSDDKLCGTL | KSEIATQELT | GEKFLEMANP | ||||
| NVAGLEAGSI | EDIVTQRGSR | VLGSFLPEKL | FKGVSQKENT | GQQNAIISPT | ||||
| VLETSEEKTV | SLTVCSAVKT | EKTPQEKLRE | SPGSEQTPFM | TAPEGKGNGG | ||||
| VNPEPFRATQ | NVFTRQLCLE | HDEKLVSYLS | LLRNIEMRTK | QIQPLELNLA | ||||
| ELQDLLCQAK | VLERELKDLT | TLVSQELECV | NQIIISQPQE | VPAQLLKALE | ||||
| KDAKNLQKSL | SSVSDTWNSR | LLHFQNAVEI | EKTKVLNQHT | QLEGRLQDLR | ||||
| AWVGNKNLIL | NSKGSNSEID | VDSLNLCLQQ | YEDLKQPMAE | RKAQLDALAF | ||||
| DIQFFISEHA | QDLSPQQNRQ | MLRLLNELQR | SFQDILEQTA | AQVDALQGHL | ||||
| QQMEQEALVK | TLQKQQNTCH | QQLEDLCSWV | GQAERALAGH | QGRTTQQDLS | ||||
| ALQKNQSDLK | DLQDDIQNRA | TSFATVVKDI | EGFMEENQTK | LSPRELTALR | ||||
| EKLHQAKEQY | EALQEETRVA | QKELEEAVTS | ALQQETEKSK | AAKELAENKK | ||||
| KIDALLDWVT | SVGSSGGQLL | TNLPGMEQLS | GASLEKGALD | TTDGYMGVNQ | ||||
| APEKLDKQCE | MMKARHQELL | SQQQNFILAT | QSAQAFLDQH | GHNLTPEEQQ | ||||
| MLQQKLGELK | EQYSTSLAQS | EAELKQVQTL | QDELQKFLQD | HKEFESWLER | ||||
| SEKELENMHK | GGSSPETLPS | LLKRQGSFSE | DVISHKGDLR | FVTISGQKVL | ||||
| DMENSFKEGK | EPSEIGNLVK | DKLKDATERY | TALHSKCTRL | GSHLNMLLGQ | ||||
| YHQFQNSADS | LQAWMQACEA | NVEKLLSDTV | ASDPGVLQEQ | LATTKQLQEE | ||||
| LAEHQVPVEK | LQKVARDIME | IEGEPAPDHR | HVQETTDSIL | SHFQSLSYSL | ||||
| AERSSLLQKA | IAQSQSVQES | LESLLQSIGE | VEQNLEGKQV | SSLSSGVIQE | ||||
| ALATNMKLKQ | DIARQKSSLE | ATREMVTRFM | ETADSTTAAV | LQGKLAEVSQ | ||||
| RFEQLCLQQQ | EKESSLKKLL | PQAEMFEHLS | GKLQQFMENK | SRMLASGNQP | ||||
| DQDITHFFQQ | IQELNLEMED | QQENLDTLEH | LVTELSSCGF | ALDLCQHQDR | ||||
| VQNLRKDFTE | LQKTVKEREK | DASSCQEQLD | EFRKLVRTFQ | KWLKETEGSI | ||||
| PPTETSMSAK | ELEKQIEHLK | SLLDDWASKG | TLVEEINCKG | TSLENLIMEI | ||||
| TAPDSQGKTG | SILPSVGSSV | GSVNGYHTCK | DLTEIQCDMS | DVNLKYEKLG | ||||
| GVLHERQESL | QAILNRMEEV | HKEANSVLQW | LESKEEVLKS | MDAMSSPTKT | ||||
| ETVKAQAESN | KAFLAELEQN | SPKIQKVKEA | LAGLLVTYPN | SQEAENWKKI | ||||
| QEELNSRWER | ATEVTVARQR | QLEESASHLA | CFQAAESQLR | PWLMEKELMM | ||||
| GVLGPLSIDP | NMLNAQKQQV | QFMLKEFEAR | RQQHEQLNEA | AQGILTGPGD | ||||
| VSLSTSQVQK | ELQSINQKWV | ELTDKLNSRS | SQIDQAIVKS | TQYQELLQDL | ||||
| SEKVRAVGQR | LSVQSAISTQ | PEAVKQQLEE | TSEIRSDLEQ | LDHEVKEAQT | ||||
| LCDELSVLIG | EQYLKDELKK | RLETVALPLQ | GLEDLAADRI | NRLQAALAST | ||||
| QQFQQMFDEL | RTWLDDKQSQ | QAKNCPISAK | LERLQSQLQE | NEEFQKSLNQ | ||||
| HSGSYEVIVA | EGESLLLSVP | PGEEKRTLQN | QLVELKNHWE | ELSKKTADRQ | ||||
| SRLKDCMQKA | QKYQWHVEDL | VPWIEDCKAK | MSELRVTLDP | VQLESSLLRS | ||||
| KAMLNEVEKR | RSLLEILNSA | ADILINSSEA | DEDGIRDEKA | GINQNMDAVT | ||||
| EELQAKTGSL | EEMTQRLREF | QESFKNIEKK | VEGAKHQLEI | FDALGSQACS | ||||
| NKNLEKLRAQ | QEVLQALEPQ | VDYLRNFTQG | LVEDAPDGSD | ASQLLHQAEV | ||||
| AQQEFLEVKQ | RVNSGCVMME | NKLEGIGQFH | CRVREMFSQL | ADLDDELDGM | ||||
| GAIGRDTDSL | QSQIEDVRLF | LNKIHVLKLD | IEASEAECRH | MLEEEGTLDL | ||||
| LGLKRELEAL | NKQCGKLTER | GKARQEQLEL | TLGRVEDFYR | KLKGLNDATT | ||||
| AAEEAEALQW | VVGTEVEIIN | QQLADFKMFQ | KEQVDPLQMK | LQQVNGLGQG | ||||
| LIQSAGKDCD | VQGLEHDMEE | INARWNTLNK | KVAQRIAQLQ | EALLHCGKFQ | ||||
| DALEPLLSWL | ADTEELIANQ | KPPSAEYKVV | KAQIQEQKLL | QRLLDDRKAT | ||||
| VDMLQAEGGR | IAQSAELADR | EKITGQLESL | ESRWTELLSK | AAARQKQLED | ||||
| ILVLAKQFHE | TAEPISDFLS | VTEKKLANSE | PVGTQTAKIQ | QQIIRHKALN | ||||
| EEIVNRKKNV | DQAIKNGQAL | LKQTTGEEVL | LIQEKLDGIK | TRYADITVTS | ||||
| SKALRTLEQA | RQLATKFQST | YEELTGWLRE | VEEELATSGG | QSPTGEQIPQ | ||||
| FQQRQKELKK | EVMEHRLVLD | TVNEVSRALL | ELVPWRAREG | LDKLVSDANE | ||||
| QYKLVSDTIG | QRVDEIDAAI | QRSQQYEQAA | DAELAWVAET | KRKLMALGPI | ||||
| RLEQDQTTAQ | LQVQKAFSID | IIRHKDSMDE | LFSHRSEIFG | TCGEEQKTVL | ||||
| QEKTESLIQQ | YEAISLLNSE | RYARLERAQV | LVNQFWETYE | ELSPWIEETR | ||||
| ALIAQLPSPA | IDHEQLRQQQ | EEMRQLRESI | AEHKPHIDKL | LKIGPQLKEL | ||||
| NPEEGEMVEE | KYQKAENMYA | QIKEEVRQRA | LALDEAVSQS | TQITEFHDKI | ||||
| EPMLETLENL | SSRLRMPPLI | PAEVDKIREC | ISDNKSATVE | LEKLQPSFEA | ||||
| LKRRGEELIG | RSQGADKDLA | AKEIQDKLDQ | MVFFWEDIKA | RAEEREIKFL | ||||
| DVLELAEKFW | YDMAALLTTI | KDTQDIVHDL | ESPGIDPSII | KQQVEAAETI | ||||
| KEETDGLHEE | LEFIRILGAD | LIFACGETEK | PEVRKSIDEM | NNAWENLNKT | ||||
| WKERLEKLED | AMQAAVQYQD | TLQAMFDWLD | NTVIKLCTMP | PVGTDLNTVK | ||||
| DQLNEMKEFK | VEVYQQQIEM | EKLNHQGELM | LKKATDETDR | DIIREPLTEL | ||||
| KHLWENLGEK | IAHRQHKLEG | ALLALGQFQH | ALEELMSWLT | HTEELLDAQR | ||||
| PISGDPKVIE | VELAKHHVLK | NDVLAHQATV | ETVNKAGNEL | LESSAGDDAS | ||||
| SLRSRLEAMN | QCWESVLQKT | EEREQQLQST | LQQAQGFHSE | IEDFLLELTR | ||||
| MESQLSASKP | TGGLPETARE | QLDTHMELYS | QLKAKEETYN | QLLDKGRLML | ||||
| LSRDDSGSGS | KTEQSVALLE | QKWHVVSSKM | EERKSKLEEA | LNLATEFQNS | ||||
| LQEFINWLTL | AEQSLNIASP | PSLILNTVLS | QIEEHKVFAN | EVNAHRDQII | ||||
| ELDQTGNQLK | FLSQKQDVVL | IKNLLVSVQS | RWEKVVQRSI | ERGRSLDDAR | ||||
| KRAKQFHEAW | KKLIDWLEDA | ESHLDSELEI | SNDPDKIKLQ | LSKHKEFQKT | ||||
| LGGKQPVYDT | TIRTGRALKE | KTLLPEDSQK | LDNFLGEVRD | KWDTVCGKSV | ||||
| ERQHKLEEAL | LFSGQFMDAL | QALVDWLYKV | EPQLAEDQPV | HGDLDLVMNL | ||||
| MDAHKVFQKE | LGKRTGTVQV | LKRSGRELIE | NSRDDTTWVK | GQLQELSTRW | ||||
| DTVCKLSVSK | QSRLEQALKQ | AEVFRDTVHM | LLEWLSEAEQ | TLRFRGALPD | ||||
| DTEALQSLID | THKEFMKKVE | EKRVDVNSAV | AMGEVILAVC | HPDCITTIKH | ||||
| WITIIRARFE | EVLTWAKQHQ | QRLETALSEL | VANAELLEEL | LAWIQWAETT | ||||
| LIQRDQEPIP | QNIDRVKALI | AEHQTFMEEM | TRKQPDVDRV | TKTYKRKNIE | ||||
| PTHAPFIEKS | RSGGRKSLSQ | PTPPPMPILS | QSEAKNPRIN | QLSARWQQVW | ||||
| LLALERQRKL | NDALDRLEEL | KEFANFDFDV | WRKKYMRWMN | HKKSRVMDFF | ||||
| RRIDKDQDGK | ITRQEFIDGI | LASKFPTTKL | EMTAVADIFD | RDGDGYIDYY | ||||
| EFVAALHPNK | DAYRPTTDAD | KIEDEVTRQV | AQCKCAKRFQ | VEQIGENKYR | ||||
| FGDSQQLRLV | RILRSTVMVR | VGGGWMALDE | FLVKNDPCRA | RGRTNIELRE | ||||
| KFILPEGASQ | GMTPFRSRGR | RSKPSSRAAS | PTRSSSSASQ | SNHSCTSMPS | ||||
| SPATPASGTK | VIPSSGSKLK | RPTPTFHSSR | TSLAGDTSNS | SSPASTGAKT | ||||
| NRADPKKSAS | RPGSRAGSRA | GSRASSRRGS | DASDFDLLET | QSACSDTSES | ||||
| SAAGGQGNSR | RGLNKPSKIP | TMSKKTTTAS | PRTPGPKR |
Кодований геном білок за функцією належить до фосфопротеїнів. Задіяний у таких біологічних процесах як сигнальний шлях Wnt, поліморфізм, ацетиляція, альтернативний сплайсинг. Білок має сайт для зв'язування з молекулою актину, іонами металів, іоном кальцію. Локалізований у клітинній мембрані, цитоплазмі, цитоскелеті, мембрані, клітинних відростках, апараті гольджі.
Література
ред.- Gong T.-W.L., Besirli C.G., Lomax M.I. (2001). MACF1 gene structure: a hybrid of plectin and dystrophin. Mamm. Genome. 12: 852—861. PMID 11845288 DOI:10.1007/s00335-001-3037-3
- Kakinuma T., Ichikawa H., Tsukada Y., Nakamura T., Toh B.H. (2004). Interaction between p230 and MACF1 is associated with transport of a glycosyl phosphatidyl inositol-anchored protein from the Golgi to the cell periphery. Exp. Cell Res. 298: 388—398. PMID 15265687 DOI:10.1016/j.yexcr.2004.04.047
- Lin C.-M., Chen H.-J., Leung C.L., Parry D.A.D., Liem R.K.H. (2005). Microtubule actin crosslinking factor 1b: a novel plakin that localizes to the Golgi complex. J. Cell Sci. 118: 3727—3738. PMID 16076900 DOI:10.1242/jcs.02510
- Zaoui K., Benseddik K., Daou P., Salaun D., Badache A. (2010). ErbB2 receptor controls microtubule capture by recruiting ACF7 to the plasma membrane of migrating cells. Proc. Natl. Acad. Sci. U.S.A. 107: 18517—18522. PMID 20937854 DOI:10.1073/pnas.1000975107
Примітки
ред.- ↑ Human PubMed Reference:.
- ↑ Mouse PubMed Reference:.
- ↑ HUGO Gene Nomenclature Commitee, HGNC:13664 (англ.) . Процитовано 28 серпня 2017.
{{cite web}}: Обслуговування CS1: Сторінки з параметром url-status, але без параметра archive-url (посилання) - ↑ UniProt, Q9UPN3 (англ.) . Архів оригіналу за 17 серпня 2017. Процитовано 28 серпня 2017.
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