English: Three-dimensional reconstruction of the KATP channel. (A) Cryo-EM density map of the KATP channel complex at an overall resolution of 5.8 Å, viewed from the side. The four Kir6.2 subunits in the center are colored blue, SUR1 is in orange (TMD0), lavender (L0), green (TMD1/NBD1), and yellow (TMD2/NBD2). Gray bars indicate approximate positions of the lipid bilayer. (B) View of the complex from the cytoplasmic side. (C and D) Cross-sections of the density map. The planes where the sections 1 and 2 are made are shown in (A). (E) Model of SUR1 and Kir6.2 constructed from the EM density map viewed from the side. A Kir6.2 tetramer and only two SUR1 subunits are shown for clarity. (F) The model viewed from the extracellular side.