Українська: KATP channel gating model. (A) Cartoon illustrating how changes in the ATP/ADP ratio upon feeding and fasting alter the equilibrium between the inward-facing and outward-facing states of the SUR1-ABC core and interactions of the channel with ATP and PIP2 to control channel activity. (B) Model of the hypothesized mechanism whereby GBC causes misalignment of the NBDs to prevent Mg-nucleotides activation of KATP channels. In both A and B, Kir6.2 transmembrane helices: green; Kir6.2 cytoplasmic domain: lime green; SUR1-TMD0/L0: magenta; SUR1-TMD1/2: blue; SUR1-NBDs: orange; GBC: yellow; ATP: red; PIP2: cerulean. Note the different states shown are not meant to reflect the actual conformational transitions.