Ангіотензиноген

Ангіотензиноген (англ. Angiotensinogen) – білок, який кодується геном AGT, розташованим у людей на короткому плечі першої хромосоми. Довжина поліпептидного ланцюга білка становить 485 амінокислот, а молекулярна маса — 53 154.

ангіотензиноген
Наявні структури PDB Пошук ортологів: PDBe RCSB Список кодів PDB 2WXW, 2X0B, 4APH,%%s1N9U, 1N9V,%%s1N9V, 1N9U, 3CK0, 4AA1, 4APH, 5E2Q
Ідентифікатори
Символи	AGT, ANHU, SERPINA8, hFLT1, angiotensinogen
Зовнішні ІД	MGI: 87963 HomoloGene: 14 GeneCards: AGT
Онтологія гена Молекулярна функція • GO:0001948, GO:0016582 protein binding • serine-type endopeptidase inhibitor activity • type 1 angiotensin receptor binding • hormone activity • superoxide-generating NADPH oxidase activator activity • growth factor activity • type 2 angiotensin receptor binding • sodium channel regulator activity • angiotensin receptor binding • receptor ligand activity Клітинна компонента • цитоплазма • екзосома • blood microparticle • міжклітинний простір • гіалоплазма • extracellular region • collagen-containing extracellular matrix Біологічний процес • uterine smooth muscle contraction • renal system process • vasoconstriction • GO:0048554 positive regulation of catalytic activity • positive regulation of cardiac muscle hypertrophy • cell surface receptor signaling pathway • cellular response to mechanical stimulus • stress-activated MAPK cascade • artery smooth muscle contraction • regulation of systemic arterial blood pressure by renin-angiotensin • regulation of apoptotic process • negative regulation of neurotrophin TRK receptor signaling pathway • regulation of long-term neuronal synaptic plasticity • positive regulation of renal sodium excretion • positive regulation of fibroblast proliferation • cellular sodium ion homeostasis • ERK1 and ERK2 cascade • activation of phospholipase C activity • angiotensin maturation • positive regulation of extracellular matrix constituent secretion • positive regulation of blood pressure • negative regulation of cell growth • regulation of norepinephrine secretion • жіноча вагітність • negative regulation of tissue remodeling • регуляція серцевого ритму • smooth muscle cell proliferation • regulation of calcium ion transport • regulation of transmission of nerve impulse • cell growth involved in cardiac muscle cell development • response to muscle activity involved in regulation of muscle adaptation • positive regulation of nitric oxide biosynthetic process • angiotensin-mediated drinking behavior • cell-cell signaling • GO:0010260 старіння людини • вазодилатація • positive regulation of cell population proliferation • fibroblast proliferation • negative regulation of angiogenesis • positive regulation of superoxide anion generation • positive regulation of L-lysine import across plasma membrane • positive regulation of cardiac muscle cell apoptotic process • positive regulation of vascular associated smooth muscle cell proliferation • positive regulation of cytosolic calcium ion concentration • negative regulation of endopeptidase activity • positive regulation of vascular associated smooth muscle cell migration • regulation of molecular function • regulation of lipid metabolic process • positive regulation of L-arginine import across plasma membrane • regulation of signaling receptor activity • positive regulation of neuron projection development • response to estradiol • cellular response to angiotensin • protein import into nucleus • associative learning • оперантне обумовлення • GO:1903106 positive regulation of insulin receptor signaling pathway • regulation of extracellular matrix assembly • positive regulation of cholesterol esterification • phospholipase C-activating G protein-coupled receptor signaling pathway • blood vessel remodeling • positive regulation of reactive oxygen species metabolic process • positive regulation of extrinsic apoptotic signaling pathway • GO:0051247, GO:0051200 positive regulation of protein metabolic process • positive regulation of branching involved in ureteric bud morphogenesis • розвиток нирки • GO:0060469, GO:0009371 positive regulation of transcription, DNA-templated • positive regulation of peptidyl-tyrosine phosphorylation • positive regulation of inflammatory response • positive regulation of protein tyrosine kinase activity • regulation of blood pressure • positive regulation of macrophage derived foam cell differentiation • regulation of vasoconstriction • positive regulation of NF-kappaB transcription factor activity • positive regulation of NAD(P)H oxidase activity • nitric oxide mediated signal transduction • G protein-coupled receptor signaling pathway coupled to cGMP nucleotide second messenger • positive regulation of epidermal growth factor receptor signaling pathway • regulation of blood volume by renin-angiotensin • regulation of cardiac conduction • maintenance of blood vessel diameter homeostasis by renin-angiotensin • regulation of renal sodium excretion • GO:0032737 positive regulation of cytokine production • positive regulation of membrane hyperpolarization • negative regulation of sodium ion transmembrane transporter activity • renin-angiotensin regulation of aldosterone production • positive regulation of endothelial cell migration • low-density lipoprotein particle remodeling • regulation of cell population proliferation • regulation of cell growth • positive regulation of gap junction assembly • positive regulation of phosphatidylinositol 3-kinase signaling • angiotensin-activated signaling pathway • negative regulation of gene expression • regulation of renal output by angiotensin • positive regulation of activation of Janus kinase activity • G protein-coupled receptor signaling pathway Джерела:Amigo / QuickGO
Шаблон експресії
Більше даних
Ортологи
Види	Людина	Миша
Entrez	183	11606
Ensembl	ENSG00000135744	ENSMUSG00000031980
UniProt	P01019	P11859 Q3UTR7
RefSeq (мРНК)	NM_000029 NM_001382817 NM_001384479	NM_007428
RefSeq (білок)	NP_000020 NP_001369746	NP_031454
Локус (UCSC)	Хр. 1: 230.69 – 230.75 Mb	Хр. 8: 125.28 – 125.3 Mb
PubMed search
Вікідані
Див./Ред. для людей Див./Ред. для мишей

Послідовність амінокислот

10		20		30		40		50
MRKRAPQSEM		APAGVSLRAT		ILCLLAWAGL		AAGDRVYIHP		FHLVIHNEST
CEQLAKANAG		KPKDPTFIPA		PIQAKTSPVD		EKALQDQLVL		VAAKLDTEDK
LRAAMVGMLA		NFLGFRIYGM		HSELWGVVHG		ATVLSPTAVF		GTLASLYLGA
LDHTADRLQA		ILGVPWKDKN		CTSRLDAHKV		LSALQAVQGL		LVAQGRADSQ
AQLLLSTVVG		VFTAPGLHLK		QPFVQGLALY		TPVVLPRSLD		FTELDVAAEK
IDRFMQAVTG		WKTGCSLMGA		SVDSTLAFNT		YVHFQGKMKG		FSLLAEPQEF
WVDNSTSVSV		PMLSGMGTFQ		HWSDIQDNFS		VTQVPFTESA		CLLLIQPHYA
SDLDKVEGLT		FQQNSLNWMK		KLSPRTIHLT		MPQLVLQGSY		DLQDLLAQAE
LPAILHTELN		LQKLSNDRIR		VGEVLNSIFF		ELEADEREPT		ESTQQLNKPE
VLEVTLNRPF		LFAVYDQSAT		ALHFLGRVAN		PLSTA

A: Аланін
C: Цистеїн
D: Аспарагінова кислота
E: Глутамінова кислота
F: Фенілаланін
G: Гліцин
H: Гістидин
I: Ізолейцин
K: Лізин
L: Лейцин
M: Метіонін
N: Аспарагін
P: Пролін
Q: Глутамін
R: Аргінін
S: Серин
T: Треонін
V: Валін
W: Триптофан

Y: Тирозин

Цей білок за функціями належить до вазоактивних білків, вазоконстрикторів (має судинозвужуючий ефект). Регулятор артеріального тиску та водно-сольового обміну організму. Секретований назовні.

Див. також

• Ренін-ангіотензинова система

Література

• Kageyama R., Ohkubo H., Nakanishi S. (1984). Primary structure of human preangiotensinogen deduced from the cloned cDNA sequence. Biochemistry. 23: 3603—3609. PMID 6089875 DOI:10.1021/bi00311a006
• Gaillard I., Clauser E., Corvol P. (1989). Structure of human angiotensinogen gene. DNA. 8: 87—99. PMID 2924688 DOI:10.1089/dna.1.1989.8.87
• The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 14: 2121—2127. 2004. PMID 15489334 DOI:10.1101/gr.2596504
• Kunapuli S.P., Kumar A. (1987). Molecular cloning of human angiotensinogen cDNA and evidence for the presence of its mRNA in rat heart. Circ. Res. 60: 786—790. PMID 2885106 DOI:10.1161/01.RES.60.5.786
• Kunapuli S.P., Benedict C.R., Kumar A. (1987). Tissue specific hormonal regulation of the rat angiotensinogen gene expression. Arch. Biochem. Biophys. 254: 642—646. PMID 3579322 DOI:10.1016/0003-9861(87)90148-2
• Tewksbury D.A., Dart R.A., Travis J. (1981). The amino terminal amino acid sequence of human angiotensinogen. Biochem. Biophys. Res. Commun. 99: 1311—1315. PMID 7259779 DOI:10.1016/0006-291X(81)90762-2